UDP-galactose and acetyl-CoA transporters as <italic>Plasmodium</italic> multidrug resistance genes
نویسندگان
چکیده
Michelle Yi-Xiu Lim1,2†, Gregory LaMonte3†, Marcus C. S. Lee4,5, Christin Reimer3, Bee Huat Tan1, Victoria Corey3, Bianca F. Tjahjadi1,6, Adeline Chua1, Marie Nachon3, René Wintjens7, Peter Gedeck1, Benoit Malleret6,8, Laurent Renia8, Ghislain M. C. Bonamy1, Paul Chi-Lui Ho2, Bryan K. S. Yeung1, Eric D. Chow9, Liting Lim1, David A. Fidock4,10, Thierry T. Diagana1,6, Elizabeth A. Winzeler* and Pablo Bifani*
منابع مشابه
Topology of UDP-galactose cleavage in relation to N-acetyl-lactosamine formation in Golgi vesicles. Translocation of activated galactose.
UDP-galactose appears to be produced on one side of a membrane barrier, opposite the galactosyltransferases that use it as a sugar donor. The translocation of activated galactose across membranes was studied in rat submaxillary-gland microsomal vesicles and in rat liver Golgi vesicles. When these intact vesicles containing the acceptor, N-acetylglucosamine, were incubated in the presence of UDP...
متن کاملFamilial melanoma-astrocytoma syndrome: synchronous diffuse astrocytoma and pleomorphic xanthoastrocytoma in a patient with germline CDKN2A/B deletion and a significant family history
Familial melanoma-astrocytoma syndrome is a tumor predisposition syndrome caused by inactivating germline alteration of the CDKN2A tumor suppressor gene on chromosome 9p21. While some families with germline CDKN2A mutations are prone to development of just melanomas, other families develop both melanomas, astrocytomas, and occasionally other nervous-system neop...
متن کاملUnraveling gene-gene interactions regulated by ligands of the aryl hydrocarbon receptor.
The co-expression of genes coupled to additive probabilistic relationships was used to identify gene sets predictive of the complex biological interactions regulated by ligands of the aryl hydrocarbon receptor ((Italic)Ahr(/Italic)). To maximize the number of possible gene-gene combinations, data sets from murine embryonic kidney, fetal heart, and vascular smooth muscle cells challenged (Italic...
متن کاملOxidative Stress Acts on Special Membrane Proteins To Reduce the Viability of <italic>Pseudomonas syringae</italic> pv <italic>tomato</italic>
Reactive oxygen species (ROS) play a vital role in reducing the viability of invading pathogens during plant-pathogen interactions. To understand how oxidative stress caused by ROS reduces cell viability, it is important to identify the proteins affected by ROS. In the present study, we investigated the changes in the expression of proteins from the outer and inner membrane fractions in Pseudom...
متن کاملCorrelations between forced oscillation technique parameters and pulmonary densitovolumetry values in patients with acromegaly.
The aims of this study were to evaluate the forced oscillation technique (FOT) and pulmonary densitovolumetry in acromegalic patients and to examine the correlations between these findings. In this cross-sectional study, 29 non-smoking acromegalic patients and 17 paired controls were subjected to the FOT and quantification of lung volume using multidetector computed tomography (Q-MDCT). Comp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2016